This is not an osteoclast

Bone Is Not Essential for Osteoclast Activation

BACKGROUND The mechanism whereby bone activates resorptive behavior in osteoclasts, the cells that resorb bone, is unknown. It is known that α(v)β(3) ligands are important, because blockade of α(v)β(3) receptor signaling inhibits bone resorption, but this might be through inhibition of adhesion or migration rather than resorption itself. Nor is it known whether α(v)β(3) ligands are sufficient f...

When is it an osteoclast?

Using acid phosphatase as a marker, osteoclasts were examined from single sections of undemineralised iliac crest biopsies from patients with renal failure and from normal controls. Eighty one per cent of the cells from controls and 56% of the cells from patients with renal failure appeared to be non-nucleated or mononucleated. Serial sections showed, however, that 73% of the control cells were...

When is it an osteoclast?

Neuroscience: This Is Not a Spider

Long-term memories of fear have been notoriously difficult to alter. A new study finds access through the window of reconsolidation.

This Is Not Your Grandfather's Emergency Department.